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KMID : 1161420130160070625
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Journal of Medicinal Food
2013 Volume.16 No. 7 p.625 ~ p.632
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The Relative Abundance of Oxygen Alkyl-Related Groups in Aliphatic Domains Is Involved in the Main Pharmacological-Pleiotropic Effects of Humic Acids
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Vetvicka Vaclav
Vashishta Aruna
Fuentes Marta
Baigorri Roberto
Garcia-Mina Jose M.
Yvin Jean-Claude
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Abstract
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Despite the rather common presence of humic acid (HA), our full knowledge of its biological effect is still lacking. In this article, we first performed a physicochemical characterization of several HAs, and next, we evaluated their ability to affect interleukin-2 secretion, antibody secretion, wound healing (an in vitro model using HaCaT cells), cancer growth (the Lewis lung carcinoma model), and protection against hepatotoxicity. In all tested reactions, HA showed significant stimulation on immune reactions, including suppression of cancer growth and inhibition of lipopolysaccharide-induced hepatotoxicity. These effects were dependent on its chemical properties. The pleiotropic effects of HA observed in this article suggest the possible role of these compounds in human nutrition.
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KEYWORD
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antibodies, hepatotoxicity, humic acids, IL-2
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